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KMID : 0370220100540020112
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Yakhak Hoeji
2010 Volume.54 No. 2 p.112 ~ p.121
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The Cytotoxic Activity of 3,4,5-Trihydroxybenzoic Acid Methylester and Related Compounds against Skin and Oral Cancer Cell Lines
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Lee Jae-Sug
Han Du-Seok
Kang Jeong-Il
Baek Jong-Min
Baek Seung-Hwa
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Abstract
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The cytotoxic activity of 33,4,5-trihydroxybenzoic acid methylester and related compounds on the growth of normal cell lines, human skin melanoma cells and human oral epithelioid cell line were evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and 2,3-bis-[2-methoxy-4-nitro-5-sulfo-phenyl]-2-H-tetrazolium-5-caboxanilide (XTT) methods. 3,4,5-Trihydroxybenzoic acid methylester decreased the cell viability of human skin melanoma cells and human oral epithelioid cells shown by the MTT method and the cell adhesion activity of human skin melanoma cells and human oral epithelioid cells shown by the XTT method. In light microscopy, 100 3,4,5-trihydroxybenzoic acid methylester showed the highest cytotoxic activity. These results suggest that 3,4,5-trihydroxybenzoic acid methylester has a potential anticancer activity.
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KEYWORD
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cytotoxic activity, NIH 3T3 fibroblasts, MTT and XTT methods, 3, 4, 5-trihydroxybenzoic acid methylester, human oral epithelioid cells, human skin melanoma cells
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